Heat Shock Protein Therapy for Muscle Wasting

Grant number: 1065456 | Funding period: 2014 - 2019

Completed

Abstract

Heat shock proteins help stressed proteins fold back to their original conformation and restore function. In a discovery published in Nature we identified induction of heat shock protein 72 (Hsp72) as a novel approach for muscular dystrophy and other conditions where there is inflammation and muscle weakness. This proposal will investigate whether Hsp72 induction is similarly effective in tackling the muscle wasting and weakness in conditions like ageing and frailty and in muscle injury.

Related publications (7)

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Defective lysosome reformation during autophagy causes skeletal muscle disease

MJ McGrath, MJ Eramo, R Gurung, A Sriratana, SM Gehrig, GS Lynch, SR Lourdes, F Koentgen, SJ Feeney, M Lazarou, CA McLean, CA Mitchell

2021-01-04

The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We showed that the inositol polyphosphate 5-phospha..

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Aging and Skeletal Muscle

Gordon S Lynch

2020-01-01

Some of the most serious consequences of aging are its effects on skeletal muscle particularly the progressive loss of mass and fu..

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HSP70 drives myoblast fusion during C2C12 myogenic differentiation

SS Thakur, K Swiderski, VL Chhen, JL James, NJ Cranna, AM Taufiqual Islam, JG Ryall, GS Lynch

2020-01-01

In response to injury, skeletal muscle stem cells (MuSCs) undergo myogenesis where they become activated, proliferate rapidly, dif..

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Expression and localization of heat-shock proteins during skeletal muscle cell proliferation and differentiation and the impact of heat stress

SS Thakur, JL James, NJ Cranna, VL Chhen, K Swiderski, JG Ryall, GS Lynch

2019-07-01

Skeletal myogenesis is a coordinated sequence of events associated with dramatic changes in cell morphology, motility, and metabol..

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Overcoming nature's paradox in skeletal muscle to optimise animal production

GS Lynch, R Koopman

2019-01-01

Nature's paradox in skeletal muscle describes the seemingly mutually exclusive relationship between muscle fibre size and oxidativ..

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Dietary meat and protection against sarcopenia

GS Lynch, R Koopman

2018-10-01

Sarcopenia describes the age-related loss of skeletal muscle mass and associated muscle weakness. Sarcopenia is a major global hea..

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Therapeutic potential of heat shock protein induction for muscular dystrophy and other muscle wasting conditions

SS Thakur, K Swiderski, JG Ryall, GS Lynch

2018-01-19

Duchennemuscular dystrophy is the most common and severe of the muscular dystrophies, a group of inherited myopathies caused by di..

University of Melbourne Researchers